RRM2B

Protein sy'n cael ei godio yn y corff dynol gan y genyn RRM2B yw RRM2B a elwir hefyd yn Ribonucleotide reductase regulatory TP53 inducible subunit M2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q22.3.

RRM2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VUX, 3HF1, 4DJN
Dynodwyr
Cyfenwau	RRM2B, MTDPS8A, MTDPS8B, P53R2, ribonucleotide reductase regulatory TP53 inducible subunit M2B, RCDFRD
Dynodwyr allanol	OMIM: 604712 HomoloGene: 56723 GeneCards: RRM2B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001948, GO:0016582 protein binding • oxidoreductase activity • ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Cydrannau o'r gell • mitocondria • cnewyllyn cell • nucleoplasm • cytoplasm • cytosol • ribonucleoside-diphosphate reductase complex Prosesau biolegol • deoxyribonucleoside triphosphate metabolic process • renal system process • kidney development • GO:0001306 response to oxidative stress • mitochondrial DNA replication • cellular response to DNA damage stimulus • deoxyribonucleotide biosynthetic process • DNA replication • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • response to amine • GO:0100026 DNA repair • nucleobase-containing small molecule interconversion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	50484	n/a
Ensembl	ENSG00000048392	n/a
UniProt	Q7LG56	n/a
RefSeq (mRNA)	NM_015713 NM_001172477 NM_001172478	n/a
RefSeq (protein)	NP_001165948 NP_001165949 NP_056528	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RRM2B.

• P53R2
• MTDPS8A
• MTDPS8B

Llyfryddiaeth

• "Synergism between clofarabine and decitabine through p53R2: a pharmacodynamic drug-drug interaction modeling. ". Leuk Res. 2012. PMID 22884950.
• "Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells. ". Proc Natl Acad Sci U S A. 2012. PMID 22847445.
• RRM2B-Related Mitochondrial Disease. 1993. PMID 24741716.
• "Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. ". Hepatology. 2014. PMID 24214128.
• "p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells.". J Dermatol Sci. 2012. PMID 22902076.