RUNX1T1

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUNX1T1 yw RUNX1T1 a elwir hefyd yn CBFA2T1 isoform r1t1-7d56 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q21.3.

RUNX1T1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WQ6, 2DJ8, 2H7B, 2KYG, 2OD1, 2ODD, 2PP4, 4JOL
Dynodwyr
Cyfenwau	RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, AML1-MTG8, t(8;21)(q22;q22), RUNX1 translocation partner 1, RUNX1 partner transcriptional co-repressor 1
Dynodwyr allanol	OMIM: 133435 HomoloGene: 3801 GeneCards: RUNX1T1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity • metal ion binding Cydrannau o'r gell • nuclear matrix • cnewyllyn cell • nucleoplasm Prosesau biolegol • negative regulation of fat cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • generation of precursor metabolites and energy • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	862	n/a
Ensembl	ENSG00000079102	n/a
UniProt	Q06455	n/a
RefSeq (mRNA)	NM_001198625 NM_001198626 NM_001198627 NM_001198628 NM_001198629 NM_001198630 NM_001198631 NM_001198632 NM_001198633 NM_001198634 NM_001198679 NM_004349 NM_175634 NM_175635 NM_175636 NM_001395209	n/a
RefSeq (protein)	NP_001185554 NP_001185555 NP_001185556 NP_001185557 NP_001185558 NP_001185559 NP_001185560 NP_001185561 NP_001185562 NP_001185563 NP_001185608 NP_004340 NP_783552 NP_783553 NP_783554 NP_783553.1 NP_783554.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUNX1T1.

• CDR
• ETO
• MTG8
• AML1T1
• ZMYND2
• CBFA2T1
• AML1-MTG8

Llyfryddiaeth

• "Assessing the miRNA sponge potential of RUNX1T1 in t(8;21) acute myeloid leukemia. ". Gene. 2017. PMID 28322996.
• "Runt-related Transcription Factor 1 (RUNX1T1) Suppresses Colorectal Cancer Cells Through Regulation of Cell Proliferation and Chemotherapeutic Drug Resistance. ". Anticancer Res. 2016. PMID 27798886.
• "RUNX1T1/MTG8/ETO gene expression status in human t(8;21)(q22;q22)-positive acute myeloid leukemia cells. ". Leuk Res. 2014. PMID 24976338.
• "Runx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microglia. ". PLoS One. 2014. PMID 24586690.
• "Mutational analysis of RUNX1T1 gene in acute leukemias, breast and lung carcinomas.". Leuk Res. 2011. PMID 21571369.