RUNX3

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUNX3 yw RUNX3 a elwir hefyd yn Runt related transcription factor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.11.

RUNX3
Dynodwyr
Cyfenwau	RUNX3, AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3
Dynodwyr allanol	OMIM: 600210 HomoloGene: 37914 GeneCards: RUNX3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948, GO:0016582 protein binding • ATP binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleolus • intracellular membrane-bounded organelle • nucleoplasm • cytosol • core-binding factor complex Prosesau biolegol • peripheral nervous system neuron development • GO:0009373 regulation of transcription, DNA-templated • chondrocyte differentiation • ossification • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • negative regulation of epithelial cell proliferation • regulation of cell differentiation • response to transforming growth factor beta • hemopoiesis • negative regulation of CD4-positive, alpha-beta T cell differentiation • positive regulation of CD8-positive, alpha-beta T cell differentiation • neuron differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	864	n/a
Ensembl	ENSG00000020633	n/a
UniProt	Q13761	n/a
RefSeq (mRNA)	NM_001031680 NM_004350 NM_001320672	n/a
RefSeq (protein)	NP_001026850 NP_001307601 NP_004341	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUNX3.

• AML2
• CBFA3
• PEBP2aC

Llyfryddiaeth

• "Runx3 plays a critical role in restriction-point and defense against cellular transformation. ". Oncogene. 2017. PMID 28846108.
• "Aberrant methylation of RUNX3 is present in Aflatoxin B1-induced transformation of the L02R cell line. ". Toxicology. 2017. PMID 28458013.
• "[Knockdown of RUNX3 inhibits hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016. PMID 27916094.
• "An early biomarker and potential therapeutic target of RUNX 3 hypermethylation in breast cancer, a system review and meta-analysis. ". Oncotarget. 2017. PMID 27825140.
• "RUNX3 reverses cisplatin resistance in esophageal squamous cell carcinoma via suppression of the protein kinase B pathway.". Thorac Cancer. 2016. PMID 27766776.