S100A12

Protein sy'n cael ei godio yn y corff dynol gan y genyn S100A12 yw S100A12 a elwir hefyd yn S100 calcium binding protein A12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.

S100A12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E8A, 1GQM, 1ODB, 2M9G, 2WC8, 2WCB, 2WCE, 2WCF
Dynodwyr
Cyfenwau	S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, S100 calcium binding protein A12, EN-RAGE
Dynodwyr allanol	OMIM: 603112 HomoloGene: 48361 GeneCards: S100A12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • RAGE receptor binding • copper ion binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • Cellbilen • extracellular region • Cytosgerbwd • cnewyllyn cell • secretory granule lumen Prosesau biolegol • mast cell activation • positive regulation of inflammatory response • positive regulation of MAP kinase activity • monocyte chemotaxis • immune system process • defense response to fungus • neutrophil chemotaxis • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • positive regulation of I-kappaB kinase/NF-kappaB signaling • xenobiotic metabolic process • innate immune response • inflammatory response • neutrophil degranulation • antimicrobial humoral immune response mediated by antimicrobial peptide • killing of cells of other organism Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6283	n/a
Ensembl	ENSG00000163221	n/a
UniProt	P80511	n/a
RefSeq (mRNA)	NM_005621	n/a
RefSeq (protein)	NP_005612	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn S100A12.

• p6
• CAGC
• CGRP
• MRP6
• CAAF1
• MRP-6
• ENRAGE

Llyfryddiaeth

• "S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. ". PLoS Pathog. 2016. PMID 27355424.
• "Circulating S100A12 Levels Are Associated with Progression of Abdominal Aortic Calcification in Hemodialysis Patients. ". PLoS One. 2016. PMID 26914918.
• "S100A12 in renal and cardiovascular diseases. ". Life Sci. 2017. PMID 29080693.
• "S100A12: Friend or foe in pulmonary tuberculosis?". Cytokine. 2017. PMID 28110121.
• "S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis.". J Invest Dermatol. 2017. PMID 27840235.