SASH1

Protein sy'n cael ei godio yn y corff dynol gan y genyn SASH1 yw SASH1 a elwir hefyd yn SAM and SH3 domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q24.3-q25.1.

SASH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EBP
Dynodwyr
Cyfenwau	SASH1, SH3D6A, dJ323M4, dJ323M4.1, SAM and SH3 domain containing 1, DUH1, CAPOK
Dynodwyr allanol	OMIM: 607955 HomoloGene: 69182 GeneCards: SASH1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • mitogen-activated protein kinase kinase kinase binding • GO:0032947 molecular adaptor activity • protein C-terminus binding • protein kinase binding Cydrannau o'r gell • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of endothelial cell migration • positive regulation of lipopolysaccharide-mediated signaling pathway • positive regulation of JUN kinase activity • regulation of protein K63-linked ubiquitination • positive regulation of p38MAPK cascade • regulation of protein autoubiquitination • protein polyubiquitination • positive regulation of NIK/NF-kappaB signaling • positive regulation of angiogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23328	n/a
Ensembl	ENSG00000111961	n/a
UniProt	O94885	n/a
RefSeq (mRNA)	NM_015278 NM_001346505 NM_001346506 NM_001346507 NM_001346508 NM_001346509	n/a
RefSeq (protein)	NP_001333434 NP_001333435 NP_001333436 NP_001333437 NP_001333438 NP_056093	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SASH1.

• SH3D6A
• dJ323M4.1

Llyfryddiaeth

• "SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer. ". Oncotarget. 2016. PMID 27637080.
• "16P The overexpression of SASH1 stimulates cell death in lung cancer cells. ". J Thorac Oncol. 2016. PMID 27198373.
• "Involvement of PI3K/Akt pathway in the inhibition of hepatocarcinoma cell invasion and metastasis induced by SASH1 through downregulating Shh-Gli1 signaling. ". Int J Biochem Cell Biol. 2017. PMID 28600143.
• "A Novel De novo Mutation of the SASH1 Gene in a Chinese Family with Multiple Lentigines. ". Acta Derm Venereol. 2017. PMID 27840890.
• "Lentiginous phenotypes caused by diverse pathogenic genes (SASH1 and PTPN11): clinical and molecular discrimination.". Clin Genet. 2016. PMID 27659786.