SERPINA3

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINA3 yw SERPINA3 a elwir hefyd yn Alpha-1-antichymotrypsin a Serpin family A member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.13.

SERPINA3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AS4, 1QMN, 2ACH, 3CAA, 3DLW, 4CAA
Dynodwyr
Cyfenwau	SERPINA3, AACT, ACT, GIG24, GIG25, serpin family A member 3
Dynodwyr allanol	OMIM: 107280 HomoloGene: 111129 GeneCards: SERPINA3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • DNA binding • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • blood microparticle • extracellular exosome • intracellular anatomical structure • cnewyllyn cell • platelet alpha granule lumen • extracellular region • extracellular space • secretory granule lumen • azurophil granule lumen • collagen-containing extracellular matrix Prosesau biolegol • regulation of lipid metabolic process • negative regulation of peptidase activity • inflammatory response • maintenance of gastrointestinal epithelium • acute-phase response • platelet degranulation • negative regulation of endopeptidase activity • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	12	n/a
Ensembl	ENSG00000196136	n/a
UniProt	P01011	n/a
RefSeq (mRNA)	NM_001085	n/a
RefSeq (protein)	NP_001076	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINA3.

• ACT
• AACT
• GIG24
• GIG25

Llyfryddiaeth

• "Up-regulation of SERPINA3 correlates with high mortality of melanoma patients and increased migration and invasion of cancer cells. ". Oncotarget. 2017. PMID 27213583.
• "Is Alpha-1 Antichymotrypsin Gene Polymorphism a Risk Factor for Primary Intracerebral Hemorrhage? A Case-Control Study and Meta-Analysis. ". Med Sci Monit. 2015. PMID 26210716.
• "Proteome demonstration of alpha-1-acid glycoprotein and alpha-1-antichymotrypsin candidate biomarkers for diagnosis of enterovirus 71 infection. ". Pediatr Infect Dis J. 2015. PMID 25170552.
• "SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. ". Int J Clin Exp Pathol. 2014. PMID 24817931.
• "PSA forms complexes with α1-antichymotrypsin in prostate.". Prostate. 2013. PMID 22806587.