SERPINF2

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINF2 yw SERPINF2 a elwir hefyd yn Alpha-2-antiplasmin a Serpin family F member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.3.

SERPINF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2R9Y
Dynodwyr
Cyfenwau	SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI, serpin family F member 2, alpha2AP
Dynodwyr allanol	OMIM: 613168 HomoloGene: 719 GeneCards: SERPINF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • protein homodimerization activity • protease binding • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase inhibitor activity • endopeptidase inhibitor activity Cydrannau o'r gell • blood microparticle • fibrinogen complex • extracellular region • cell surface • extracellular exosome • platelet alpha granule lumen • extracellular space • collagen-containing extracellular matrix Prosesau biolegol • positive regulation of collagen biosynthetic process • negative regulation of peptidase activity • negative regulation of fibrinolysis • negative regulation of plasminogen activation • maintenance of blood vessel diameter homeostasis by renin-angiotensin • blood vessel morphogenesis • fibrinolysis • collagen fibril organization • platelet degranulation • positive regulation of JNK cascade • response to organic substance • acute-phase response • positive regulation of cell differentiation • positive regulation of ERK1 and ERK2 cascade • positive regulation of transforming growth factor beta production • positive regulation of stress fiber assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of smooth muscle cell proliferation • positive regulation of cell-cell adhesion mediated by cadherin • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5345	n/a
Ensembl	ENSG00000167711 ENSG00000276838	n/a
UniProt	P08697	n/a
RefSeq (mRNA)	NM_000934 NM_001165920 NM_001165921	n/a
RefSeq (protein)	NP_000925 NP_001159392 NP_001159393	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINF2.

• AAP
• API
• PLI
• A2AP
• ALPHA-2-PI

Llyfryddiaeth

• "Natural heterogeneity of α2-antiplasmin: functional and clinical consequences. ". Blood. 2016. PMID 26626994.
• "The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm. ". Thromb Res. 2014. PMID 25065555.
• "Evaluation of serum fibrinogen, plasminogen, α2-anti-plasmin, and plasminogen activator inhibitor levels (PAI) and their correlation with presence of retinopathy in patients with type 1 DM. ". J Diabetes Res. 2014. PMID 24818165.
• "Increased N-terminal cleavage of alpha-2-antiplasmin in patients with liver cirrhosis. ". J Thromb Haemost. 2013. PMID 24034420.
• "Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis).". Am J Respir Crit Care Med. 2013. PMID 23992406.