SHH

SHH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3HO5, 3M1N, 3MXW
Dynodwyr
Cyfenwau	SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, sonic hedgehog, Sonic hedgehog, ShhNC, sonic hedgehog signaling molecule
Dynodwyr allanol	OMIM: 600725 HomoloGene: 30961 GeneCards: SHH
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • metal ion binding; • patched binding; • GO:0070122 peptidase activity; • zinc ion binding; • laminin-1 binding; • glycosaminoglycan binding; • morphogen activity; • hydrolase activity; • GO:0001948, GO:0016582 protein binding; • endopeptidase activity;
Cydrannau o'r gell	• cytosol; • endoplasmic reticulum lumen; • bilen; • cell surface; • membrane raft; • Cellbilen; • extracellular space; • extracellular region; • GO:0005578 extracellular matrix;
Prosesau biolegol	• positive regulation of skeletal muscle cell proliferation; • pattern specification process; • myotube differentiation; • mesenchymal cell proliferation; • male genitalia development; • bud outgrowth involved in lung branching; • limb bud formation; • T cell differentiation in thymus; • embryonic pattern specification; • positive regulation of skeletal muscle tissue development; • positive regulation of immature T cell proliferation in thymus; • positive regulation of kidney smooth muscle cell differentiation; • negative regulation of Wnt signaling pathway; • anatomical structure formation involved in morphogenesis; • ectoderm development; • hindgut morphogenesis; • spinal cord dorsal/ventral patterning; • GO:0007364, GO:0007361, GO:0007358 formation of anatomical boundary; • oligodendrocyte differentiation; • trachea development; • prostate gland development; • negative regulation of transcription elongation from RNA polymerase II promoter; • limb development; • vasculogenesis; • primary prostatic bud elongation; • heart looping; • telencephalon regionalization; • odontogenesis of dentin-containing tooth; • positive regulation of mesenchymal cell proliferation; • angiogenesis; • positive regulation of epithelial cell proliferation involved in prostate gland development; • positive regulation of striated muscle cell differentiation; • negative regulation of proteasomal ubiquitin-dependent protein catabolic process; • embryonic digestive tract morphogenesis; • apoptotic signaling pathway; • inner ear development; • hair follicle morphogenesis; • cell population proliferation; • metanephros development; • lung epithelium development; • negative regulation of canonical Wnt signaling pathway; • regulation of proteolysis; • branching involved in salivary gland morphogenesis; • negative regulation of mesenchymal cell apoptotic process; • positive regulation of neuroblast proliferation; • dopaminergic neuron differentiation; • intermediate filament organization; • renal system development; • cell fate commitment; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of smoothened signaling pathway; • androgen metabolic process; • kidney development; • lung development; • GO:1903363 negative regulation of protein catabolic process; • thymus development; • embryonic organ development; • negative regulation of cell differentiation; • negative regulation of dopaminergic neuron differentiation; • embryonic digit morphogenesis; • negative regulation of alpha-beta T cell differentiation; • positive regulation of sclerotome development; • epithelial-mesenchymal cell signaling; • negative regulation of gene expression; • lymphoid progenitor cell differentiation; • negative thymic T cell selection; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of Wnt signaling pathway; • ventral midline development; • central nervous system development; • heart development; • branching involved in ureteric bud morphogenesis; • negative regulation of T cell proliferation; • embryonic limb morphogenesis; • positive regulation of cell differentiation; • branching involved in prostate gland morphogenesis; • positive regulation of mesenchymal cell proliferation involved in ureter development; • establishment of cell polarity; • branching involved in blood vessel morphogenesis; • positive regulation of cerebellar granule cell precursor proliferation; • neuroblast proliferation; • pancreas development; • positive regulation of protein import into nucleus; • smoothened signaling pathway; • oligodendrocyte development; • camera-type eye development; • spinal cord motor neuron differentiation; • positive regulation of alpha-beta T cell differentiation; • digestive tract morphogenesis; • hair follicle development; • positive regulation of oligodendrocyte differentiation; • roof of mouth development; • left lung development; • striated muscle tissue development; • positive regulation of T cell differentiation in thymus; • cellular response to lithium ion; • embryonic foregut morphogenesis; • GO:1903374 anatomical structure development; • thalamus development; • stem cell development; • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; • cell fate specification; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; • proteolysis; • embryonic skeletal system development; • regulation of protein localization to nucleus; • odontogenesis; • respiratory tube development; • regulation of prostatic bud formation; • thyroid gland development; • negative regulation of cell migration; • developmental growth; • right lung development; • determination of left/right asymmetry in lateral mesoderm; • positive thymic T cell selection; • mesenchymal smoothened signaling pathway involved in prostate gland development; • canonical Wnt signaling pathway; • regulation of gene expression; • osteoblast development; • negative regulation of cholesterol efflux; • dorsal/ventral neural tube patterning; • regulation of epithelial cell proliferation involved in prostate gland development; • epithelial-mesenchymal signaling involved in prostate gland development; • dorsal/ventral pattern formation; • branching morphogenesis of an epithelial tube; • lung lobe morphogenesis; • embryonic forelimb morphogenesis; • midbrain development; • skin development; • regulation of odontogenesis; • regulation of mesenchymal cell proliferation involved in prostate gland development; • mesenchymal cell proliferation involved in lung development; • positive regulation of hh target transcription factor activity; • prostate epithelial cord elongation; • metanephric mesenchymal cell proliferation involved in metanephros development; • endocytosis; • lung morphogenesis; • cell development; • trachea morphogenesis; • epithelial cell proliferation involved in salivary gland morphogenesis; • cell-cell signaling; • salivary gland cavitation; • hindbrain development; • blood coagulation; • negative regulation of kidney smooth muscle cell differentiation; • somite development; • cerebellar granule cell precursor proliferation; • axon guidance; • negative regulation of ureter smooth muscle cell differentiation; • positive regulation of ureter smooth muscle cell differentiation; • multicellular organism development; • animal organ formation; • intein-mediated protein splicing; • determination of left/right symmetry; • vasculature development; • GO:1901313 positive regulation of gene expression; • regulation of cell population proliferation; • embryonic morphogenesis; • neural crest cell migration; • polarity specification of anterior/posterior axis; • positive regulation of cell population proliferation; • artery development; • protein localization to nucleus; • Bergmann glial cell differentiation; • forebrain development; • neuron fate commitment; • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; • striated muscle cell differentiation; • myoblast differentiation; • lung-associated mesenchyme development; • epithelial tube branching involved in lung morphogenesis; • positive regulation of cell division; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • anterior/posterior pattern specification; • embryonic hindlimb morphogenesis; • forebrain regionalization; • cell proliferation in external granule layer; • tracheoesophageal septum formation; • regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	6469
	n/a
	ENSG00000164690
	n/a
	Q15465
	n/a
	NM_000193; NM_001310462
	n/a
	NP_000184; NP_001297391
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SHH yw SHH a elwir hefyd yn Sonic hedgehog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q36.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SHH.

TPT
HHG1
HLP3
HPE3
SMMCI
ShhNC
TPTPS
MCOPCB5

Llyfryddiaeth

"Oral Squamous Cell Carcinoma-derived Sonic Hedgehog Promotes Angiogenesis. ". Anticancer Res. 2017. PMID 29187450.
"Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands. ". Br J Cancer. 2017. PMID 28881358.
"Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway. ". Biochem Biophys Res Commun. 2017. PMID 28870814.
"Transcriptional Profiling of Sonic Hedgehog in a Prospective Cohort of Breast Cancer in a Pakistani Population. ". Anticancer Res. 2017. PMID 28739739.
"Comparative Analysis of Mutational Profile of Sonic hedgehog Gene in Gallbladder Cancer.". Dig Dis Sci. 2017. PMID 28058596.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SHH - Cronfa NCBI

[2]

[1]