SIRT5

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIRT5 yw SIRT5 a elwir hefyd yn Sirtuin 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p23.

SIRT5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2B4Y, 2NYR, 3RIG, 3RIY, 4F4U, 4F56, 4G1C, 4HDA, 5BWL
Dynodwyr
Cyfenwau	SIRT5, SIR2L5, sirtuin 5
Dynodwyr allanol	OMIM: 604483 HomoloGene: 40825 GeneCards: SIRT5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hydrolase activity • metal ion binding • NAD+ ADP-ribosyltransferase activity • NAD+ binding • protein-succinyllysine desuccinylase activity • protein-malonyllysine demalonylase activity • zinc ion binding • NAD-dependent protein deacetylase activity • protein-glutaryllysine deglutarylase activity Cydrannau o'r gell • cytoplasm • mitochondrial intermembrane space • mitocondria • cnewyllyn cell • cytosol • mitochondrial matrix • mitochondrial inner membrane Prosesau biolegol • protein deacetylation • negative regulation of cardiac muscle cell apoptotic process • response to nutrient levels • protein ADP-ribosylation • negative regulation of reactive oxygen species metabolic process • peptidyl-lysine deglutarylation • mitochondrion organization • regulation of ketone biosynthetic process • protein demalonylation • peptidyl-lysine demalonylation • protein desuccinylation • peptidyl-lysine desuccinylation • protein deglutarylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23408	n/a
Ensembl	ENSG00000124523	n/a
UniProt	Q9NXA8	n/a
RefSeq (mRNA)	NM_001193267 NM_001242827 NM_012241 NM_031244	n/a
RefSeq (protein)	NP_001180196 NP_001229756 NP_036373 NP_112534 NP_001363727 NP_001363728 NP_001363729 NP_001363730 NP_001363731 NP_001363732 NP_001363733 NP_001363734 NP_001363735 NP_001363736 NP_001363737 NP_001363738 NP_001363739 NP_001363740 NP_001363741 NP_001363742 NP_001363743 NP_001363744	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SIRT5.

• SIR2L5

Llyfryddiaeth

• "Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. ". Mol Cell Proteomics. 2015. PMID 25717114.
• "Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors. ". Angew Chem Int Ed Engl. 2014. PMID 25111069.
• "A Selective Cyclic Peptidic Human SIRT5 Inhibitor. ". Molecules. 2016. PMID 27626398.
• "Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells. ". Neurotox Res. 2017. PMID 27577743.
• "Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.". PLoS One. 2016. PMID 27023330.