SKP1

Protein sy'n cael ei godio yn y corff dynol gan y genyn SKP1 yw SKP1 a elwir hefyd yn S-phase kinase associated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.1.

SKP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FQV, 1FS1, 1FS2, 1LDK, 1P22, 2ASS, 2AST, 2E31, 2E32, 2OVP, 2OVQ, 2OVR, 3L2O, 3WSO, 4I6J, 5IBK
Dynodwyr
Cyfenwau	SKP1, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, S-phase kinase associated protein 1
Dynodwyr allanol	OMIM: 601434 HomoloGene: 38775 GeneCards: SKP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cullin family protein binding • beta-catenin binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0001948, GO:0016582 protein binding • GO:0050372 ubiquitin-protein transferase activity • protein domain specific binding Cydrannau o'r gell • cytoplasm • nucleoplasm • PcG protein complex • cnewyllyn cell • cytosol • SCF ubiquitin ligase complex • Cul7-RING ubiquitin ligase complex • centrosome Prosesau biolegol • ubiquitin-dependent protein catabolic process • histone H2A monoubiquitination • NIK/NF-kappaB signaling • G2/M transition of mitotic cell cycle • stress-activated MAPK cascade • protein ubiquitination • protein polyubiquitination • Wnt signaling pathway • SCF complex assembly • negative regulation of G2/M transition of mitotic cell cycle • maintenance of protein location in nucleus • cellular iron ion homeostasis • post-translational protein modification • interleukin-1-mediated signaling pathway • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • GO:0022415 viral process • regulation of mitotic cell cycle phase transition • stimulatory C-type lectin receptor signaling pathway • Fc-epsilon receptor signaling pathway • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6500	n/a
Ensembl	ENSG00000113558	n/a
UniProt	P63208	n/a
RefSeq (mRNA)	NM_170679 NM_006930	n/a
RefSeq (protein)	NP_008861 NP_733779	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SKP1.

• OCP2
• p19A
• EMC19
• SKP1A
• OCP-II
• TCEB1L

Llyfryddiaeth

• "OCP2 immunoreactivity in the human fetal cochlea at weeks 11, 17, 20, and 28, and the human adult cochlea. ". Hear Res. 2002. PMID 12117534.
• "OCP2 exists as a dimer in the organ of Corti. ". Hear Res. 1998. PMID 9872132.
• "Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinson׳s disease. ". Environ Res. 2013. PMID 23988235.
• "Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease. ". Neurodegener Dis. 2012. PMID 22205206.
• "Suppression of S-phase kinase-associated protein 2 induces apoptosis and inhibits tumor growth in human laryngeal cancer.". ORL J Otorhinolaryngol Relat Spec. 2010. PMID 20668394.