SLC9A3R1

SLC9A3R1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1G9O, 1GQ4, 1GQ5, 1I92, 2D10, 2JXO, 2KJD, 2KRG, 2M0T, 2M0U, 2M0V, 2OZF, 4JL7, 4LMM, 4MPA, 4N6X, 4PQW, 4Q3H
Dynodwyr
Cyfenwau	SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2, Sodium-hydrogen antiporter 3 regulator 1, SLC9A3 regulator 1
Dynodwyr allanol	OMIM: 604990 HomoloGene: 3137 GeneCards: SLC9A3R1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein self-association; • growth factor receptor binding; • dopamine receptor binding; • beta-catenin binding; • beta-2 adrenergic receptor binding; • phosphatase binding; • signaling receptor binding; • GO:0032947 molecular adaptor activity; • GO:0001948, GO:0016582 protein binding; • GO:0032403 protein-containing complex binding; • protein domain specific binding; • chloride channel regulator activity; • PDZ domain binding; • myosin II binding; • protein N-terminus binding;
Cydrannau o'r gell	• brush border membrane; • fesigl; • endomembrane system; • cnewyllyn cell; • cyrion cell; • cell projection; • actin cytoskeleton; • perinuclear region of cytoplasm; • apical part of cell; • ruffle; • stereocilium; • extracellular exosome; • bilen; • membrane raft; • microvillus membrane; • cytoplasm; • microvillus; • stereocilium tip; • apical plasma membrane; • sperm midpiece; • filopodium; • Cellbilen; • intracellular membrane-bounded organelle;
Prosesau biolegol	• negative regulation of cell population proliferation; • regulation of protein kinase activity; • positive regulation of intrinsic apoptotic signaling pathway; • regulation of cell size; • actin cytoskeleton organization; • renal absorption; • regulation of sodium:proton antiporter activity; • phospholipase C-activating dopamine receptor signaling pathway; • microvillus assembly; • bile acid secretion; • cAMP-mediated signaling; • establishment of Golgi localization; • clyw; • renal phosphate ion absorption; • gland morphogenesis; • negative regulation of cell motility; • negative regulation of protein kinase B signaling; • auditory receptor cell stereocilium organization; • negative regulation of phosphatidylinositol 3-kinase signaling; • establishment of epithelial cell apical/basal polarity; • negative regulation of ERK1 and ERK2 cascade; • adenylate cyclase-activating dopamine receptor signaling pathway; • GO:0044061 regulation of excretion; • cellular phosphate ion homeostasis; • negative regulation of mitotic cell cycle; • glutathione transport; • renal sodium ion transport; • negative regulation of sodium:proton antiporter activity; • negative regulation of platelet-derived growth factor receptor signaling pathway; • negative regulation of cell migration; • regulation of cell shape; • Wnt signaling pathway; • negative regulation of sodium ion transport; • nuclear migration; • protein localization to plasma membrane; • positive regulation of ion transmembrane transport; • GO:0034622 protein-containing complex assembly; • negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	9368
	n/a
	ENSG00000109062
	n/a
	O14745
	n/a
	NM_004252
	n/a
	NP_004243
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLC9A3R1 yw SLC9A3R1 a elwir hefyd yn SLC9A3 regulator 1 a Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLC9A3R1.

EBP50
NHERF
NHERF1
NHERF-1
NPHLOP2

Llyfryddiaeth

"Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance. ". Oncogene. 2017. PMID 28068322.
"A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression. ". Anticancer Res. 2017. PMID 28011475.
"NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition. ". Anticancer Res. 2017. PMID 28739734.
"Controllable Activation of Nanoscale Dynamics in a Disordered Protein Alters Binding Kinetics. ". J Mol Biol. 2017. PMID 28285124.
"NHERF1 Enhances Cisplatin Sensitivity in Human Cervical Cancer Cells.". Int J Mol Sci. 2017. PMID 28085111.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SLC9A3R1 - Cronfa NCBI

[2]

[1]