SMAD2

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD2 yw SMAD2 a elwir hefyd yn Mothers against decapentaplegic homolog 2 a SMAD family member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.1.

SMAD2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DEV, 1KHX, 1U7V, 2LB3
Dynodwyr
Cyfenwau	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD8
Dynodwyr allanol	OMIM: 601366 HomoloGene: 21197 GeneCards: SMAD2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatase binding • I-SMAD binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • R-SMAD binding • co-SMAD binding • transcription factor binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transforming growth factor beta receptor binding • type I transforming growth factor beta receptor binding • protein homodimerization activity • chromatin binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • SMAD binding • DNA binding • protein heterodimerization activity • ubiquitin protein ligase binding • primary miRNA binding • disordered domain specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • tau protein binding Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • heteromeric SMAD protein complex • SMAD protein complex • transcription regulator complex • intracellular anatomical structure • nucleoplasm • activin responsive factor complex • GO:0009327 protein-containing complex Prosesau biolegol • pattern specification process • ureteric bud development • endoderm development • response to cholesterol • organ growth • embryonic pattern specification • zygotic specification of dorsal/ventral axis • post-embryonic development • protein phosphorylation • pericardium development • regulation of binding • transforming growth factor beta receptor signaling pathway • negative regulation of cell population proliferation • cell fate commitment • common-partner SMAD protein phosphorylation • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • lung development • signal transduction involved in regulation of gene expression • insulin secretion • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of gene expression • nodal signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • pancreas development • endoderm formation • activin receptor signaling pathway • SMAD protein complex assembly • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • embryonic foregut morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • positive regulation of epithelial to mesenchymal transition • developmental growth • gastrulation • GO:1990744, GO:1990729 primary miRNA processing • positive regulation of BMP signaling pathway • embryonic cranial skeleton morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • paraxial mesoderm morphogenesis • GO:0007243 intracellular signal transduction • somatic stem cell population maintenance • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • GO:1901313 positive regulation of gene expression • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • transcription by RNA polymerase II • protein deubiquitination • wound healing • adrenal gland development • secondary palate development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4087	n/a
Ensembl	ENSG00000175387	n/a
UniProt	Q15796	n/a
RefSeq (mRNA)	NM_001003652 NM_001135937 NM_005901	n/a
RefSeq (protein)	NP_001003652 NP_001129409 NP_005892	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD2.

• JV18
• MADH2
• MADR2
• JV18-1
• hMAD-2
• hSMAD2

Llyfryddiaeth

• "SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections. ". Hum Mutat. 2015. PMID 26247899.
• "Involvement of smad2 and Erk/Akt cascade in TGF-β1-induced apoptosis in human gingival epithelial cells. ". Cytokine. 2015. PMID 25882870.
• "High p-Smad2 expression in stromal fibroblasts predicts poor survival in patients with clinical stage I to IIIA non-small cell lung cancer. ". World J Surg Oncol. 2014. PMID 25373709.
• "Ammonium chloride inhibits autophagy of hepatocellular carcinoma cells through SMAD2 signaling. ". Tumour Biol. 2015. PMID 25342595.
• "Overexpression of Smad2 inhibits proliferation of gingival epithelial cells.". J Periodontal Res. 2014. PMID 23738652.