SMAD3

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD3 yw SMAD3 a elwir hefyd yn SMAD family member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q22.33.

SMAD3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Dynodwyr
Cyfenwau	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
Dynodwyr allanol	OMIM: 603109 HomoloGene: 55937 GeneCards: SMAD3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatase binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • R-SMAD binding • co-SMAD binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • enzyme binding • transforming growth factor beta receptor binding • protein homodimerization activity • collagen binding • zinc ion binding • chromatin binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • protein kinase binding • sequence-specific DNA binding • DNA binding • bHLH transcription factor binding • ubiquitin binding • identical protein binding • protein heterodimerization activity • chromatin DNA binding • ubiquitin protein ligase binding • beta-catenin binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • DEAD/H-box RNA helicase binding • mineralocorticoid receptor binding • glucocorticoid receptor binding • primary miRNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SMAD binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001104 transcription coregulator activity Cydrannau o'r gell • cytoplasm • cnewyllyn cell • heteromeric SMAD protein complex • SMAD protein complex • transcription regulator complex • receptor complex • Cellbilen • intracellular anatomical structure • nucleoplasm • nuclear inner membrane • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • somitogenesis • skeletal system development • ureteric bud development • endoderm development • regulation of transforming growth factor beta2 production • embryonic pattern specification • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of osteoblast differentiation • heart looping • positive regulation of chondrocyte differentiation • positive regulation of alkaline phosphatase activity • positive regulation of interleukin-1 beta production • pericardium development • regulation of binding • negative regulation of wound healing • activation of cysteine-type endopeptidase activity involved in apoptotic process • transforming growth factor beta receptor signaling pathway • negative regulation of inflammatory response • positive regulation of positive chemotaxis • negative regulation of cell population proliferation • negative regulation of fat cell differentiation • cell-cell junction organization • GO:0009373 regulation of transcription, DNA-templated • extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • signal transduction involved in regulation of gene expression • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • nodal signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cell growth • regulation of immune response • positive regulation of transforming growth factor beta3 production • T cell activation • activin receptor signaling pathway • regulation of striated muscle tissue development • embryonic foregut morphogenesis • positive regulation of bone mineralization • wound healing • negative regulation of apoptotic process • positive regulation of extracellular matrix assembly • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of epithelial to mesenchymal transition • GO:0019049, GO:0030683 mitigation of host defenses by virus • thyroid gland development • developmental growth • lens fiber cell differentiation • gastrulation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • osteoblast differentiation • GO:1990744, GO:1990729 primary miRNA processing • negative regulation of osteoblast proliferation • osteoblast development • embryonic cranial skeleton morphogenesis • transdifferentiation • paraxial mesoderm morphogenesis • response to hypoxia • positive regulation of cell migration • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • GO:1901313 positive regulation of gene expression • immune system development • positive regulation of focal adhesion assembly • liver development • regulation of epithelial cell proliferation • positive regulation of stress fiber assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of mitotic cell cycle • negative regulation of cytosolic calcium ion concentration • canonical Wnt signaling pathway • protein stabilization • transcription, DNA-templated • GO:1903363 negative regulation of protein catabolic process • protein deubiquitination • positive regulation of nitric oxide biosynthetic process • negative regulation of lung blood pressure • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of cardiac muscle hypertrophy in response to stress • cellular response to transforming growth factor beta stimulus • cellular response to cytokine stimulus • positive regulation of protein import into nucleus • positive regulation of DNA-binding transcription factor activity • SMAD protein signal transduction • positive regulation of canonical Wnt signaling pathway • SMAD protein complex assembly • adrenal gland development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4088	n/a
Ensembl	ENSG00000166949	n/a
UniProt	P84022	n/a
RefSeq (mRNA)	NM_001145102 NM_001145103 NM_001145104 NM_005902	n/a
RefSeq (protein)	NP_001138574 NP_001138575 NP_001138576 NP_005893	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD3.

• LDS3
• LDS1C
• MADH3
• JV15-2
• HSPC193
• HsT17436

Llyfryddiaeth

• "The SMAD3 transcription factor binds complex RNA structures with high affinity. ". Nucleic Acids Res. 2017. PMID 29036649.
• "Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3. ". Biochem Biophys Res Commun. 2017. PMID 28450107.
• "Endovascular Repair of Internal Mammary Artery Aneurysms in 2 Sisters with SMAD3 Mutation. ". Ann Vasc Surg. 2017. PMID 28286188.
• "Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers. ". J Allergy Clin Immunol. 2017. PMID 28011059.
• "SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?". Biol Reprod. 2016. PMID 27683263.