SMAD7

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD7 yw SMAD7 a elwir hefyd yn SMAD family member 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.1.

SMAD7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ
Dynodwyr
Cyfenwau	SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7
Dynodwyr allanol	OMIM: 602932 HomoloGene: 4314 GeneCards: SMAD7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • beta-catenin binding • type I transforming growth factor beta receptor binding • collagen binding • I-SMAD binding • activin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • centrosome • transcription regulator complex • Cellbilen • intracellular anatomical structure • nucleoplasm • catenin complex • cnewyllyn cell • fibrillar center • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • cellular response to transforming growth factor beta stimulus • regulation of ventricular cardiac muscle cell membrane depolarization • pathway-restricted SMAD protein phosphorylation • ureteric bud development • GO:0009373 regulation of transcription, DNA-templated • adherens junction assembly • positive regulation of cell-cell adhesion • ventricular septum morphogenesis • regulation of epithelial to mesenchymal transition • negative regulation of peptidyl-threonine phosphorylation • negative regulation of transcription by competitive promoter binding • response to laminar fluid shear stress • protein stabilization • regulation of activin receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of DNA-binding transcription factor activity • negative regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of BMP signaling pathway • ventricular cardiac muscle tissue morphogenesis • negative regulation of protein ubiquitination • negative regulation of cell migration • negative regulation of ubiquitin-protein transferase activity • artery morphogenesis • negative regulation of peptidyl-serine phosphorylation • regulation of cardiac muscle contraction • positive regulation of protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of epithelial to mesenchymal transition • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of transforming growth factor beta receptor signaling pathway • transcription, DNA-templated • transforming growth factor beta receptor signaling pathway • protein deubiquitination • negative regulation of T cell cytokine production • negative regulation of T-helper 17 type immune response • negative regulation of T-helper 17 cell differentiation • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4092	n/a
Ensembl	ENSG00000101665	n/a
UniProt	O15105	n/a
RefSeq (mRNA)	NM_005904 NM_001190821 NM_001190822 NM_001190823	n/a
RefSeq (protein)	NP_001177750 NP_001177751 NP_001177752 NP_005895	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD7.

• CRCS3
• MADH7
• MADH8

Llyfryddiaeth

• "The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis. ". BMC Med Genet. 2017. PMID 29084532.
• "MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia. ". Gene. 2017. PMID 28732737.
• "Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death. ". Cell Death Dis. 2017. PMID 28300830.
• "High Smad7 sustains inflammatory cytokine response in refractory coeliac disease. ". Immunology. 2017. PMID 27861825.
• "SMAD7 loci contribute to risk of hepatocellular carcinoma and clinicopathologic development among Chinese Han population.". Oncotarget. 2016. PMID 26989026.