SMG5

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMG5 yw SMG5 a elwir hefyd yn SMG5, nonsense mediated mRNA decay factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q22.

SMG5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HWY
Dynodwyr
Cyfenwau	SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
Dynodwyr allanol	OMIM: 610962 HomoloGene: 9095 GeneCards: SMG5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein phosphatase 2A binding • histone deacetylase binding • GO:0001948, GO:0016582 protein binding • telomeric DNA binding • ubiquitin protein ligase binding • ribonuclease activity • ribonucleoprotein complex binding • telomerase RNA binding Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • telomerase holoenzyme complex Prosesau biolegol • regulation of dephosphorylation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mRNA export from nucleus • regulation of telomere maintenance • regulation of telomere maintenance via telomerase • regulation of RNA stability • RNA phosphodiester bond hydrolysis • telomere maintenance via telomerase Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23381	n/a
Ensembl	ENSG00000198952	n/a
UniProt	Q9UPR3	n/a
RefSeq (mRNA)	NM_015327 NM_001323614 NM_001323615 NM_001323616 NM_001323617	n/a
RefSeq (protein)	NP_001310543 NP_001310544 NP_001310545 NP_001310546 NP_056142	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMG5.

• EST1B
• SMG-5
• LPTSRP1
• LPTS-RP1

Llyfryddiaeth

• "Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. ". Nucleic Acids Res. 2014. PMID 25013172.
• "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. ". Mol Cell. 2005. PMID 15721257.
• "MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA. ". BMC Mol Biol. 2016. PMID 27473591.
• "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. ". Mol Cell. 2004. PMID 15546618.
• "The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.". Cell Host Microbe. 2014. PMID 25211080.