SOX9

SOX9
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4EUW
Dynodwyr
Cyfenwau	SOX9, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9
Dynodwyr allanol	OMIM: 608160 HomoloGene: 294 GeneCards: SOX9
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • core promoter sequence-specific DNA binding; • protein kinase activity; • protein kinase A catalytic subunit binding; • beta-catenin binding; • pre-mRNA intronic binding; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • DNA binding; • sequence-specific DNA binding; • GO:0000975 transcription cis-regulatory region binding; • bHLH transcription factor binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• cnewyllyn cell; • transcription regulator complex; • nucleoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• skeletal system development; • cellular response to retinoic acid; • bronchus cartilage development; • positive regulation of protein phosphorylation; • heart valve development; • limb bud formation; • GO:1903364 positive regulation of protein catabolic process; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • ureter morphogenesis; • negative regulation of immune system process; • chondrocyte development; • positive regulation of cell proliferation involved in heart morphogenesis; • oligodendrocyte differentiation; • chondrocyte hypertrophy; • prostate gland development; • lung smooth muscle development; • mammary gland development; • negative regulation of ossification; • negative regulation of photoreceptor cell differentiation; • cellular response to mechanical stimulus; • intrahepatic bile duct development; • regulation of cell adhesion; • negative regulation of chondrocyte differentiation; • positive regulation of mesenchymal cell proliferation; • astrocyte fate commitment; • positive regulation of chondrocyte differentiation; • spermatogenesis; • prostate gland morphogenesis; • negative regulation of epithelial cell proliferation; • lung epithelial cell differentiation; • chondrocyte differentiation involved in endochondral bone morphogenesis; • negative regulation of canonical Wnt signaling pathway; • endocrine pancreas development; • negative regulation of cell population proliferation; • regulation of apoptotic process; • cellular response to transforming growth factor beta stimulus; • negative regulation of mesenchymal cell apoptotic process; • chromatin remodeling; • negative regulation of myoblast differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • cell fate commitment; • GO:0009373 regulation of transcription, DNA-templated; • epidermal growth factor receptor signaling pathway; • ossification; • regulation of cell proliferation involved in tissue homeostasis; • ureter smooth muscle cell differentiation; • ERK1 and ERK2 cascade; • notochord development; • positive regulation of epithelial cell migration; • Sertoli cell differentiation; • male sex determination; • negative regulation of gene expression; • transcription, DNA-templated; • metanephric nephron tubule formation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • regulation of branching involved in lung morphogenesis; • ureter urothelium development; • branching involved in ureteric bud morphogenesis; • cartilage development; • Harderian gland development; • positive regulation of kidney development; • central nervous system development; • heart valve formation; • positive regulation of cartilage development; • tissue homeostasis; • metanephric tubule development; • negative regulation of biomineral tissue development; • endochondral bone morphogenesis; • trachea cartilage development; • male germ-line sex determination; • lacrimal gland development; • Notch signaling pathway; • hair follicle development; • cell differentiation; • ureter development; • regulation of cell cycle process; • male gonad development; • positive regulation of epithelial cell proliferation; • cell fate specification; • intestinal epithelial structure maintenance; • positive regulation of extracellular matrix assembly; • extracellular matrix organization; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • Sertoli cell development; • positive regulation of mesenchymal stem cell differentiation; • retina development in camera-type eye; • cellular response to interleukin-1; • epithelial to mesenchymal transition; • homeostasis of number of cells within a tissue; • GO:0045996 negative regulation of transcription, DNA-templated; • cAMP-mediated signaling; • cartilage condensation; • positive regulation of male gonad development; • nucleosome assembly; • negative regulation of bone mineralization; • morphogenesis of a branching epithelium; • neural crest cell development; • protein kinase B signaling; • somatic stem cell population maintenance; • otic vesicle formation; • otic vesicle development; • endocardial cushion morphogenesis; • cellular response to epidermal growth factor stimulus; • positive regulation of epithelial cell differentiation; • renal vesicle induction; • GO:1901313 positive regulation of gene expression; • regulation of epithelial cell proliferation involved in lung morphogenesis; • regulation of cell population proliferation; • heart valve morphogenesis; • cytoskeleton organization; • cochlea morphogenesis; • positive regulation of cell population proliferation; • epithelial cell proliferation involved in prostatic bud elongation; • retinal rod cell differentiation; • protein localization to nucleus; • regulation of cell differentiation; • positive regulation of phosphatidylinositol 3-kinase signaling; • cellular response to heparin; • negative regulation of epithelial cell differentiation; • epithelial tube branching involved in lung morphogenesis; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of pri-miRNA transcription by RNA polymerase II; • chondrocyte differentiation; • neural crest cell fate specification; • cellular response to BMP stimulus; • cell-cell adhesion; • transcription initiation from RNA polymerase II promoter; • GO:0034622 protein-containing complex assembly; • anterior head development; • morphogenesis of an epithelium; • aortic valve morphogenesis; • regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologau
	6662
	n/a
	ENSG00000125398
	n/a
	P48436
	n/a
	NM_000346
	n/a
	NP_000337
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOX9 yw SOX9 a elwir hefyd yn SRY-box 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q24.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOX9.

CMD1
SRA1
CMPD1
SRXX2
SRXY10

Llyfryddiaeth

"Expression and Clinical Significance of SOX9 in Renal Cell Carcinoma, Bladder Cancer and Penile Cancer. ". Oncol Res Treat. 2017. PMID 28118628.
"Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China. ". Biomed Res Int. 2016. PMID 28090537.
"SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types. ". PLoS One. 2017. PMID 29121666.
"Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury. ". Circulation. 2017. PMID 28724751.
"Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.". Oncol Res. 2017. PMID 28277188.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SOX9 - Cronfa NCBI

[2]

[1]