SP1

Protein sy'n cael ei godio yn y corff dynol gan y genyn SP1 yw SP1 a elwir hefyd yn Sp1 transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.13.

SP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1SP1, 1SP2, 1VA1, 1VA2, 1VA3
Dynodwyr
Cyfenwau	SP1, entrez:6667, Sp1 transcription factor
Dynodwyr allanol	OMIM: 189906 HomoloGene: 8276 GeneCards: SP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • HMG box domain binding • transcription factor binding • histone deacetylase binding • metal ion binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • bHLH transcription factor binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • nucleic acid binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • DNA binding • double-stranded DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • core promoter sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001158 cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cytoplasm • nucleoplasm • protein-DNA complex • cnewyllyn cell • transcription repressor complex Prosesau biolegol • positive regulation of hydrogen sulfide biosynthetic process • proses rythmig • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0022415 viral process • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • snRNA transcription by RNA polymerase II • cellular response to insulin stimulus • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of cholesterol biosynthetic process • GO:1901313 positive regulation of gene expression • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • positive regulation of vascular endothelial cell proliferation • response to hydroperoxide Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6667	n/a
Ensembl	ENSG00000185591	n/a
UniProt	P08047	n/a
RefSeq (mRNA)	NM_001251825 NM_003109 NM_138473	n/a
RefSeq (protein)	NP_001238754 NP_003100 NP_612482	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Specificity protein 1: Its role in colorectal cancer progression and metastasis. ". Crit Rev Oncol Hematol. 2017. PMID 28427500.
• "Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression. ". Biochim Biophys Acta. 2017. PMID 28237576.
• "Effects of Cu(II) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding: Insights into the regulation of copper homeostasis and platinum drug transport. ". J Inorg Biochem. 2016. PMID 27172866.
• "Starvation after Cobalt-60 γ-Ray Radiation Enhances Metastasis in U251 Glioma Cells by Regulating the Transcription Factor SP1. ". Int J Mol Sci. 2016. PMID 27058528.
• "MiR-24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1.". Cancer Med. 2016. PMID 26922862.