SREBF1

Protein sy'n cael ei godio yn y corff dynol gan y genyn SREBF1 yw SREBF1 a elwir hefyd yn Sterol regulatory element-binding protein 1 a Sterol regulatory element binding transcription factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p11.2.

SREBF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AM9
Dynodwyr
Cyfenwau	SREBF1, SREBP-1c, SREBP1, bHLHd1, SREBP1a, sterol regulatory element binding transcription factor 1
Dynodwyr allanol	OMIM: 184756 HomoloGene: 3079 GeneCards: SREBF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sterol response element binding • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • GO:0010577 enzyme activator activity Cydrannau o'r gell • cytoplasm • integral component of membrane • cytosol • Golgi apparatus • nuclear envelope • endoplasmic reticulum membrane • bilen • intracellular membrane-bounded organelle • Golgi membrane • nucleoplasm • Reticwlwm endoplasmig • ER to Golgi transport vesicle membrane • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of histone deacetylation • GO:1901047 insulin receptor signaling pathway • positive regulation of triglyceride biosynthetic process • steroid metabolic process • negative regulation of insulin secretion • response to fatty acid • lipid biosynthetic process • response to glucagon • regulation of protein stability • GO:0009373 regulation of transcription, DNA-templated • response to retinoic acid • GO:1904578 response to organic cyclic compound • lung development • lipid metabolism • regulation of insulin secretion • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to starvation • response to progesterone • GO:0010260 heneiddio • response to peptide hormone • mRNA transcription by RNA polymerase II • cholesterol metabolic process • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to lipid • cellular response to fatty acid • regulation of autophagy of mitochondrion • regulation of protein targeting to mitochondrion • regulation of fatty acid metabolic process • Rhythm circadaidd • cellular response to insulin stimulus • response to food • positive regulation of cholesterol biosynthetic process • response to cAMP • regulation of heart rate by chemical signal • fat cell differentiation • intracellular receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of cholesterol biosynthetic process • transcription by RNA polymerase II • positive regulation of pri-miRNA transcription by RNA polymerase II • GO:0048554 positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6720	n/a
Ensembl	ENSG00000072310	n/a
UniProt	P36956	n/a
RefSeq (mRNA)	NM_001005291 NM_004176 NM_001321096	n/a
RefSeq (protein)	NP_001005291 NP_001308025 NP_004167	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SREBF1.

• SREBP1
• bHLHd1

Llyfryddiaeth

• "Comparison of TaqMan Real-Time and Tetra-Primer ARMS PCR Techniques for Genotyping of Rs 8066560 Variant in Children and Adolescents with Metabolic Syndrome. ". Adv Clin Exp Med. 2015. PMID 26771965.
• "The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility. ". Proc Natl Acad Sci U S A. 2015. PMID 26392539.
• "Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein-1 signaling. ". J Cell Physiol. 2017. PMID 28218386.
• "The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth. ". Cell Cycle. 2016. PMID 27579997.
• "Overexpression of SULT2B1b Promotes Angiogenesis in Human Gastric Cancer.". Cell Physiol Biochem. 2016. PMID 26937945.