SRF

SRF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1HBX, 1K6O, 1SRS
Dynodwyr
Cyfenwau	SRF, MCM1, serum response factor
Dynodwyr allanol	OMIM: 600589 HomoloGene: 31135 GeneCards: SRF
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • primary miRNA binding; • transcription factor binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • protein homodimerization activity; • serum response element binding; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • DNA binding; • sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • chromatin DNA binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • RNA polymerase II-specific DNA-binding transcription factor binding;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • nucleoplasm;
Prosesau biolegol	• dorsal aorta morphogenesis; • bronchus cartilage development; • muscle cell cellular homeostasis; • lung smooth muscle development; • regulation of water loss via skin; • transcription by RNA polymerase II; • stress fiber assembly; • cell migration involved in sprouting angiogenesis; • platelet activation; • cardiac myofibril assembly; • heart looping; • cellular senescence; • face development; • regulation of cell adhesion; • long-term depression; • neuron projection development; • morphogenesis of an epithelial sheet; • positive regulation of filopodium assembly; • primitive streak formation; • cellular response to glucose stimulus; • negative regulation of cell population proliferation; • response to cytokine; • GO:0009373 regulation of transcription, DNA-templated; • heart trabecula formation; • actin filament organization; • thymus development; • angiogenesis involved in wound healing; • platelet formation; • neuron development; • in utero embryonic development; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • positive regulation of cell differentiation; • branching involved in blood vessel morphogenesis; • positive regulation of axon extension; • positive regulation of smooth muscle contraction; • trachea cartilage development; • response to toxic substance; • positive regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of transcription by glucose; • regulation of smooth muscle cell differentiation; • epithelial structure maintenance; • associative learning; • skin morphogenesis; • positive regulation of DNA-binding transcription factor activity; • epithelial cell-cell adhesion; • neuron migration; • positive regulation of transcription initiation from RNA polymerase II promoter; • eyelid development in camera-type eye; • thyroid gland development; • negative regulation of amyloid-beta clearance; • negative regulation of cell migration; • developmental growth; • hematopoietic stem cell differentiation; • gastrulation; • trophectodermal cell differentiation; • positive thymic T cell selection; • response to hormone; • cell-matrix adhesion; • sarcomere organization; • actin cytoskeleton organization; • megakaryocyte development; • response to hypoxia; • lung morphogenesis; • mesoderm formation; • cardiac vascular smooth muscle cell differentiation; • mRNA transcription by RNA polymerase II; • multicellular organism development; • tangential migration from the subventricular zone to the olfactory bulb; • long-term memory; • contractile actin filament bundle assembly; • bicellular tight junction assembly; • leukocyte differentiation; • hippocampus development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • erythrocyte development; • negative regulation of pri-miRNA transcription by RNA polymerase II; • forebrain development; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologau
	6722
	n/a
	ENSG00000112658
	n/a
	P11831
	n/a
	NM_003131; NM_001292001
	n/a
	NP_001278930; NP_003122; NP_003122.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SRF yw SRF a elwir hefyd yn Serum response factor a Serum response factor (C-fos serum response element-binding transcription factor), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SRF.

MCM1

Llyfryddiaeth

"Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma. ". Int J Oncol. 2014. PMID 24173109.
"Expression of serum response factor in gastric carcinoma and its molecular mechanisms involved in the regulation of the invasion and migration of SGC-7901 cells. ". Cancer Biother Radiopharm. 2013. PMID 23134219.
"The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation. ". BMC Cancer. 2017. PMID 28249598.
"The regulatory role of serum response factor pathway in neutrophil inflammatory response. ". Curr Opin Hematol. 2015. PMID 25402621.
"The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases.". Prostate. 2014. PMID 24249383.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SRF - Cronfa NCBI

[2]

[1]