TDG

Protein sy'n cael ei godio yn y corff dynol gan y genyn TDG yw TDG a elwir hefyd yn Thymine DNA glycosylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q23.3.

TDG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WYW, 2D07, 2RBA, 3UFJ, 3UO7, 3UOB, 4FNC, 4JGC, 4XEG, 4Z3A, 4Z47, 4Z7B, 4Z7Z, 5CYS
Dynodwyr
Cyfenwau	TDG, hThymine-DNA glycosylase, thymine DNA glycosylase
Dynodwyr allanol	OMIM: 601423 HomoloGene: 2415 GeneCards: TDG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0001104 transcription coregulator activity • damaged DNA binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • hydrolase activity • protein kinase C binding • transcription factor binding • DNA N-glycosylase activity • mismatched DNA binding • protein domain specific binding • DNA binding • magnesium ion binding • uracil DNA N-glycosylase activity • ATP binding • pyrimidine-specific mismatch base pair DNA N-glycosylase activity • sodium ion binding • chloride ion binding • SUMO binding • protein self-association • G/U mismatch-specific uracil-DNA glycosylase activity Cydrannau o'r gell • PML body • Cellbilen • nucleoplasm • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • embryo development • negative regulation of chromatin binding • oxidative DNA demethylation • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of protein binding • transcription, DNA-templated • cellular response to DNA damage stimulus • depyrimidination • DNA demethylation • base-excision repair • GO:0100026 DNA repair • DNA mismatch repair • regulation of gene expression, epigenetic • base-excision repair, AP site formation • regulation of DNA N-glycosylase activity • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • regulation of embryonic development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6996	n/a
Ensembl	ENSG00000139372	n/a
UniProt	Q13569	n/a
RefSeq (mRNA)	NM_001008411 NM_003211 NM_001363612	n/a
RefSeq (protein)	NP_003202 NP_001350541	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TDG.

• hTDG

Llyfryddiaeth

• "Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. ". Nucleic Acids Res. 2015. PMID 26358812.
• "Mechanism of the Glycosidic Bond Cleavage of Mismatched Thymine in Human Thymine DNA Glycosylase Revealed by Classical Molecular Dynamics and Quantum Mechanical/Molecular Mechanical Calculations. ". J Phys Chem B. 2015. PMID 26320595.
• "Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms. ". Genes Cells. 2017. PMID 28318075.
• "Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase. ". Biochemistry. 2016. PMID 27805810.
• "Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.". J Biol Chem. 2016. PMID 26917720.