TEK

TEK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4K0V, 1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3L8P, 4X3J
Dynodwyr
Cyfenwau	TEK, CD202B, TIE-2, TIE2, VMCM, VMCM1, TEK tyrosine kinase, TEK receptor tyrosine kinase, GLC3E
Dynodwyr allanol	OMIM: 600221 HomoloGene: 397 GeneCards: TEK
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • kinase activity; • GO:0001948, GO:0016582 protein binding; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • signaling receptor activity; • growth factor binding; • receptor tyrosine kinase; • transmembrane signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • cell-cell junction; • focal adhesion; • integral component of plasma membrane; • stress fiber; • extracellular region; • microvillus; • cell surface; • basal plasma membrane; • cell junction; • basolateral plasma membrane; • apical plasma membrane; • Microffilament; • membrane raft; • Cytosgerbwd; • microtubule organizing center; • Cellbilen; • receptor complex;
Prosesau biolegol	• negative regulation of endothelial cell apoptotic process; • positive regulation of protein kinase B signaling; • positive regulation of protein phosphorylation; • response to hypoxia; • positive regulation of endothelial cell proliferation; • heart trabecula formation; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • regulation of endothelial cell apoptotic process; • cell-cell signaling; • response to peptide hormone; • sprouting angiogenesis; • negative regulation of apoptotic process; • endochondral ossification; • GO:0010740 positive regulation of intracellular signal transduction; • response to organic substance; • positive regulation of angiogenesis; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of endothelial cell migration; • response to estrogen; • heart development; • regulation of vascular permeability; • protein phosphorylation; • protein complex oligomerization; • endothelial cell proliferation; • angiogenesis; • Tie signaling pathway; • positive regulation of ERK1 and ERK2 cascade; • negative regulation of angiogenesis; • protein autophosphorylation; • positive regulation of focal adhesion assembly; • regulation of establishment or maintenance of cell polarity; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • substrate adhesion-dependent cell spreading; • response to cAMP; • definitive hemopoiesis; • positive regulation of actin cytoskeleton reorganization; • negative regulation of inflammatory response; • leukocyte migration; • GO:0072468 signal transduction; • glomerulus vasculature development; • negative regulation of signal transduction; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	7010
	n/a
	ENSG00000120156
	n/a
	Q02763
	n/a
	NM_000459; NM_001290077; NM_001290078; NM_001375475; NM_001375476
	n/a
	NP_000450; NP_001277006; NP_001277007; NP_001362404; NP_001362405
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TEK yw TEK a elwir hefyd yn Angiopoietin-1 receptor a TEK receptor tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TEK.

TIE2
VMCM
GLC3E
TIE-2
VMCM1
CD202B

Llyfryddiaeth

"Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression. ". Ophthalmology. 2016. PMID 27236272.
"Calmodulin Mediates Ca2+-Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake During Embryonic Angiogenesis. ". Arterioscler Thromb Vasc Biol. 2016. PMID 27199448.
"Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations. ". J Invest Dermatol. 2017. PMID 27519652.
"Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab. ". Br J Cancer. 2016. PMID 27351218.
"Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis.". PLoS One. 2016. PMID 27281335.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TEK - Cronfa NCBI

[2]

[1]