THRB

Protein sy'n cael ei godio yn y corff dynol gan y genyn THRB yw THRB a elwir hefyd yn Thyroid hormone receptor beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p24.2.

THRB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1
Dynodwyr
Cyfenwau	THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta
Dynodwyr allanol	OMIM: 190160 HomoloGene: 36025 GeneCards: THRB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • GO:0001106 transcription corepressor activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0001948, GO:0016582 protein binding • enzyme binding • chromatin DNA binding • thyroid hormone binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • nuclear body • RNA polymerase II transcription regulator complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • regulation of heart contraction • female courtship behavior • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • clyw • type I pneumocyte differentiation • negative regulation of female receptivity • animal organ morphogenesis • transcription initiation from RNA polymerase II promoter • GO:0045996 negative regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway • transcription, DNA-templated • negative regulation of eye photoreceptor cell development • retinal cone cell development • retinal cone cell apoptotic process • multicellular organism development • hormone-mediated signaling pathway • cell differentiation • thyroid gland development • response to lipid • thyroid hormone mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7068	n/a
Ensembl	ENSG00000151090	n/a
UniProt	P10828	n/a
RefSeq (mRNA)	NM_000461 NM_001128176 NM_001128177 NM_001252634 NM_001354708 NM_001354709 NM_001354710 NM_001354711 NM_001354712 NM_001354713 NM_001354714 NM_001354715 NM_001374822 NM_001374823 NM_001374824 NM_001374825 NM_001374826 NM_001374827	n/a
RefSeq (protein)	NP_000452 NP_001121648 NP_001121649 NP_001239563 NP_001341637 NP_001341638 NP_001341639 NP_001341640 NP_001341641 NP_001341642 NP_001341643 NP_001341644 NP_001361751 NP_001361752 NP_001361753 NP_001361754 NP_001361755 NP_001361756	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn THRB.

• GRTH
• PRTH
• THR1
• ERBA2
• NR1A2
• THRB1
• THRB2
• C-ERBA-2
• C-ERBA-BETA

Llyfryddiaeth

• "Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β. ". Mol Carcinog. 2017. PMID 27254276.
• "Molecular characterization of human thyroid hormone receptor β isoform 4. ". Endocr Res. 2016. PMID 26513165.
• "A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor. ". Mol Cell Endocrinol. 2017. PMID 28257829.
• "A new TRβ mutation in resistance to thyroid hormone syndrome. ". Hormones (Athens). 2016. PMID 28222413.
• "Thyroid hormone resistance syndrome caused by heterozygous A317T mutation in thyroid hormone receptor β gene: Report of one Chinese pedigree and review of the literature.". Medicine (Baltimore). 2016. PMID 27537566.