TNFSF11

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFSF11 yw TNFSF11 a elwir hefyd yn TNF superfamily member 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q14.11.

TNFSF11
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3URF, 5BNQ
Dynodwyr
Cyfenwau	TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNLG6B, tumor necrosis factor superfamily member 11, TNF superfamily member 11
Dynodwyr allanol	OMIM: 602642 HomoloGene: 2744 GeneCards: TNFSF11
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • tumor necrosis factor receptor superfamily binding • tumor necrosis factor receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • Cellbilen • integral component of plasma membrane • extracellular region • extracellular space Prosesau biolegol • mammary gland epithelial cell proliferation • cell differentiation • positive regulation of protein kinase B signaling • positive regulation of corticotropin-releasing hormone secretion • positive regulation of MAP kinase activity • calcium ion homeostasis • ossification • monocyte chemotaxis • cytokine-mediated signaling pathway • osteoclast differentiation • ERK1 and ERK2 cascade • paracrine signaling • positive regulation of DNA-binding transcription factor activity • positive regulation of osteoclast differentiation • tumor necrosis factor-mediated signaling pathway • GO:0010740 positive regulation of intracellular signal transduction • positive regulation of bone resorption • mammary gland alveolus development • positive regulation of JNK cascade • bone resorption • positive regulation of osteoclast development • multicellular organism development • positive regulation of T cell activation • positive regulation of homotypic cell-cell adhesion • positive regulation of NF-kappaB transcription factor activity • positive regulation of fever generation by positive regulation of prostaglandin secretion • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling • regulation of osteoclast differentiation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • animal organ morphogenesis • positive regulation of I-kappaB kinase/NF-kappaB signaling • TNFSF11-mediated signaling pathway • positive regulation of phosphorylation • protein homooligomerization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • osteoclast proliferation • calcium-mediated signaling • cellular response to leukemia inhibitory factor • regulation of signaling receptor activity • tooth eruption • bone development • GO:1901313 positive regulation of gene expression • osteoclast development • regulation of actin binding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8600	n/a
Ensembl	ENSG00000120659	n/a
UniProt	O14788	n/a
RefSeq (mRNA)	NM_003701 NM_033012	n/a
RefSeq (protein)	NP_003692 NP_143026	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFSF11.

• ODF
• OPGL
• sOdf
• CD254
• OPTB2
• RANKL
• TNLG6B
• TRANCE
• hRANKL2

Llyfryddiaeth

• "The Expression of Matrix Metalloproteinases in Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)-expressing Cancer of Apocrine Origin. ". Anticancer Res. 2018. PMID 29277763.
• "Proinsulin C-peptide modulates the expression of ERK1/2, type I collagen and RANKL in human osteoblast-like cells (Saos-2). ". Mol Cell Endocrinol. 2017. PMID 28007656.
• "Osteoprotegerin/sRANKL Signaling System in Pulmonary Sarcoidosis: A Bronchoalveolar Lavage Study. ". Adv Exp Med Biol. 2017. PMID 27826889.
• "Increased RANKL expression in peripheral T cells is associated with decreased bone mineral density in patients with COPD. ". Int J Mol Med. 2016. PMID 27279356.
• "RANKL expression is a useful marker for differentiation of pagetoid squamous cell carcinoma in situ from extramammary Paget disease.". J Cutan Pathol. 2016. PMID 27251225.