TNKS

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNKS yw TNKS a elwir hefyd yn Tankyrase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p23.1.

TNKS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2RF5, 3UDD, 3UH2, 3UH4, 4DVI, 4I9I, 4K4E, 4K4F, 4KRS, 4LI6, 4LI7, 4LI8, 4MSG, 4MSK, 4MT9, 4N3R, 4N4V, 4OA7, 4TOR, 4TOS, 4U6A, 4UUH, 4UW1, 4W5S, 4W6E, 5ECE, 5EBT, 5ETY
Dynodwyr
Cyfenwau	TNKS, ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5, tankyrase
Dynodwyr allanol	OMIM: 603303 HomoloGene: 18405 GeneCards: TNKS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glycosyltransferase activity • GO:0031493 histone binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • NAD+ ADP-ribosyltransferase activity • protein ADP-ribosylase activity Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • spindle pole • pericentriolar material • bilen • Golgi membrane • nuclear pore • Cromosom • telomere • chromosome, centromeric region • Cytosgerbwd • cnewyllyn cell • nucleoplasm • nuclear body • nuclear membrane • mitotic spindle pole • microtubule organizing center Prosesau biolegol • protein auto-ADP-ribosylation • mRNA transport • protein ADP-ribosylation • positive regulation of telomere capping • GO:0043148 mitotic spindle organization • protein polyubiquitination • protein localization to chromosome, telomeric region • Cellraniad • spindle assembly • GO:0035404 peptidyl-serine phosphorylation • positive regulation of telomerase activity • negative regulation of telomere maintenance via telomere lengthening • negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric • protein transport • cell cycle • peptidyl-threonine phosphorylation • regulation of telomere maintenance via telomerase • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein poly-ADP-ribosylation • negative regulation of telomeric DNA binding • positive regulation of canonical Wnt signaling pathway • positive regulation of telomere maintenance via telomerase • Wnt signaling pathway • cellular response to nutrient Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8658	n/a
Ensembl	ENSG00000173273 ENSG00000285372	n/a
UniProt	O95271	n/a
RefSeq (mRNA)	NM_003747	n/a
RefSeq (protein)	NP_003738	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNKS.

• TIN1
• ARTD5
• PARPL
• TINF1
• TNKS1
• pART5
• PARP5A
• PARP-5a

Llyfryddiaeth

• "Tankyrase 1 polymorphism associated with an increased risk in developing non-small cell lung cancer in a Chinese population: a proof-of-principle study. ". Int J Clin Exp Pathol. 2015. PMID 26617760.
• "The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. ". Cancer Med. 2014. PMID 24403055.
• "Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling. ". Structure. 2016. PMID 27499439.
• "Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. ". Int J Oncol. 2016. PMID 26820603.
• "Human Cytomegalovirus Inhibits the PARsylation Activity of Tankyrase--A Potential Strategy for Suppression of the Wnt Pathway.". Viruses. 2015. PMID 26729153.