TOM1

TOM1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1ELK, 1WRD, 2N2N
Dynodwyr
Cyfenwau	TOM1, target of myb1 membrane trafficking protein, IMD85
Dynodwyr allanol	OMIM: 604700 HomoloGene: 88453 GeneCards: TOM1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• clathrin binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytosol; • endosome; • early endosome; • extracellular exosome; • intracellular anatomical structure; • cytoplasm; • bilen; • Cellbilen; • azurophil granule membrane; • specific granule membrane;
Prosesau biolegol	• intracellular protein transport; • endocytosis; • endosomal transport; • protein transport; • neutrophil degranulation; • GO:0015915 transport;
	Sources:Amigo / QuickGO
Orthologau
	10043
	n/a
	ENSG00000100284
	n/a
	O60784
	n/a
	NM_001135729; NM_001135730; NM_001135732; NM_005488
	n/a
	NP_001129201; NP_001129202; NP_001129204; NP_005479
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TOM1 yw TOM1 a elwir hefyd yn Target of Myb protein 1 a Target of myb1 membrane trafficking protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q12.3.^[2]

Llyfryddiaeth

"Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. ". Biochemistry. 2000. PMID 10985773.
"Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. ". Nat Commun. 2015. PMID 26007630.
"Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease. ". J Neurol Sci. 2016. PMID 27206884.
"TOM1 is a PI5P effector involved in the regulation of endosomal maturation. ". J Cell Sci. 2015. PMID 25588840.
"The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking.". Traffic. 2010. PMID 20604899.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TOM1 - Cronfa NCBI

[2]

[1]