TP63

TP63
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1
Dynodwyr
Cyfenwau	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63
Dynodwyr allanol	OMIM: 603273 HomoloGene: 31189 GeneCards: TP63
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • metal ion binding; • damaged DNA binding; • GO:0001948, GO:0016582 protein binding; • WW domain binding; • double-stranded DNA binding; • DNA binding; • sequence-specific DNA binding; • identical protein binding; • chromatin binding; • p53 binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • MDM2/MDM4 family protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • protein domain specific binding;
Cydrannau o'r gell	• cytoplasm; • neuron projection; • cnewyllyn cell; • rough endoplasmic reticulum; • transcription regulator complex; • nucleoplasm; • dendrite; • mitocondria; • Golgi apparatus; • cytosol; • GO:0009327 protein-containing complex;
Prosesau biolegol	• pattern specification process; • skeletal system development; • epithelial cell development; • negative regulation of keratinocyte differentiation; • epidermal cell division; • anatomical structure formation involved in morphogenesis; • prostate gland development; • transcription by RNA polymerase II; • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; • ectoderm and mesoderm interaction; • cellular response to DNA damage stimulus; • female genitalia morphogenesis; • odontogenesis of dentin-containing tooth; • prostatic bud formation; • positive regulation of cell cycle G1/S phase transition; • positive regulation of mesenchymal cell proliferation; • spermatogenesis; • multicellular organism aging; • smooth muscle tissue development; • positive regulation of fibroblast apoptotic process; • animal organ morphogenesis; • hair follicle morphogenesis; • positive regulation of Notch signaling pathway; • GO:0097285 apoptotic process; • chromatin remodeling; • GO:0009373 regulation of transcription, DNA-templated; • regulation of neuron apoptotic process; • positive regulation of apoptotic signaling pathway; • regulation of cysteine-type endopeptidase activity involved in apoptotic process; • transcription, DNA-templated; • embryonic limb morphogenesis; • negative regulation of mesoderm development; • epidermis development; • post-anal tail morphogenesis; • response to gamma radiation; • protein homotetramerization; • Notch signaling pathway; • hair follicle development; • neuron apoptotic process; • polarized epithelial cell differentiation; • proximal/distal pattern formation; • cell differentiation; • positive regulation of keratinocyte proliferation; • skin morphogenesis; • epithelial cell differentiation; • urinary bladder development; • cellular response to UV; • establishment of planar polarity; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • protein tetramerization; • keratinocyte proliferation; • positive regulation of osteoblast differentiation; • regulation of epidermal cell division; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of cellular senescence; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • sympathetic nervous system development; • establishment of skin barrier; • morphogenesis of a polarized epithelium; • keratinocyte differentiation; • multicellular organism development; • mitotic G1 DNA damage checkpoint signaling; • cloacal septation; • response to X-ray; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • regulation of signal transduction by p53 class mediator; • regulation of apoptotic process; • GO:0010260 heneiddio; • negative regulation of intracellular estrogen receptor signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of somatic stem cell population maintenance; • cell population proliferation; • epidermal cell differentiation; • embryonic forelimb morphogenesis; • embryonic hindlimb morphogenesis; • skin epidermis development; • cranial skeletal system development; • GO:0007571 developmental process;
	Sources:Amigo / QuickGO
Orthologau
	8626
	n/a
	ENSG00000073282
	n/a
	Q9H3D4
	n/a
NM_001114978; NM_001114979; NM_001114980; NM_001114981; NM_001114982;
	NM_003722; NM_001329144; NM_001329145; NM_001329146; NM_001329148; NM_001329149; NM_001329150; NM_001329964
	n/a
NP_001108450; NP_001108451; NP_001108452; NP_001108453; NP_001108454;
	NP_001316073; NP_001316074; NP_001316075; NP_001316077; NP_001316078; NP_001316079; NP_001316893; NP_003713
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP63 yw TP63 a elwir hefyd yn Tumor protein p63 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q28.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP63.

AIS
KET
LMS
NBP
RHS
p40
p51
p63
EEC3
OFC8
p73H
p73L
SHFM4
TP53L
TP73L
p53CP
TP53CP
B(p51A)

Llyfryddiaeth

"Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma. ". Cancer Sci. 2017. PMID 28892579.
"p63 Adjusts Sugar Taste of Epidermal Layers. ". J Invest Dermatol. 2017. PMID 28395898.
"Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping. ". Hum Pathol. 2017. PMID 28153507.
"Decreased TAp63 and ΔNp63 mRNA Levels in Most Human Pituitary Adenomas Are Correlated with Notch3/Jagged1 Relative Expression. ". Endocr Pathol. 2017. PMID 28078618.
"ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells.". BMC Cancer. 2016. PMID 27724925.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TP63 - Cronfa NCBI

[2]

[1]