TP73

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP73 yw TP73 a elwir hefyd yn Tumor protein p73 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.32.

TP73
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4GUQ, 1COK, 1DXS, 2KBY, 2MPS, 2WQI, 2WQJ, 2WTT, 2XWC, 3VD0, 3VD1, 3VD2, 4A63, 4G82, 4G83, 4GUO
Dynodwyr
Cyfenwau	TP73, P73, tumor protein p73, CILD47
Dynodwyr allanol	OMIM: 601990 HomoloGene: 3960 GeneCards: TP73
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • chromatin binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein kinase binding • p53 binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • MDM2/MDM4 family protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • Golgi apparatus • intracellular membrane-bounded organelle • transcription regulator complex • cell junction • chromatin • cnewyllyn cell • mitocondria • nucleoplasm • cytosol Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of oligodendrocyte differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • GO:0009373 regulation of transcription, DNA-templated • negative regulation of neuron differentiation • kidney development • cellular response to UV • GO:1901227 negative regulation of transcription by RNA polymerase II • protein tetramerization • transcription, DNA-templated • cellular response to DNA damage stimulus • mitotic G1 DNA damage checkpoint signaling • response to organonitrogen compound • intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitotic cell cycle • positive regulation of apoptotic process • regulation of gene expression • DNA mismatch repair • cell cycle • negative regulation of cardiac muscle cell proliferation • GO:0022415 viral process • negative regulation of JUN kinase activity • response to gamma radiation • response to X-ray • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell population proliferation • GO:0097285 apoptotic process • regulation of signal transduction by p53 class mediator • transcription by RNA polymerase II • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7161	n/a
Ensembl	ENSG00000078900	n/a
UniProt	O15350	n/a
RefSeq (mRNA)	NM_001126240 NM_001126241 NM_001126242 NM_001204184 NM_001204185 NM_001204186 NM_001204187 NM_001204188 NM_001204189 NM_001204190 NM_001204191 NM_001204192 NM_005427	n/a
RefSeq (protein)	NP_001119712 NP_001119713 NP_001119714 NP_001191113 NP_001191114 NP_001191115 NP_001191116 NP_001191117 NP_001191118 NP_001191119 NP_001191120 NP_001191121 NP_005418	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP73.

• P73

Llyfryddiaeth

• "Aberration of p73Promoter Methylation in Chondrosarcoma. ". Anticancer Res. 2017. PMID 28551631.
• "Trifluoroethanol-induced conformational transition of the C-terminal sterile alpha motif (SAM) of human p73. ". Arch Biochem Biophys. 2017. PMID 28235466.
• "Meta-analysis of TP73 polymorphism and cervical cancer. ". Genet Mol Res. 2017. PMID 28128397.
• "Decreased expression of p73 in colorectal cancer. ". Folia Histochem Cytobiol. 2016. PMID 27654017.
• "The polymorphism G4C14-to-A4T14 in p73 gene may affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population.". Eur J Obstet Gynecol Reprod Biol. 2016. PMID 27525684.