TPM1

Protein sy'n cael ei godio yn y corff dynol gan y genyn TPM1 yw TPM1 a elwir hefyd yn Tropomyosin alpha-1 chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q22.2.

TPM1
Dynodwyr
Cyfenwau	TPM1, C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA, HEL-S-265, tropomyosin 1 (alpha), tropomyosin 1
Dynodwyr allanol	OMIM: 191010 HomoloGene: 121635 GeneCards: TPM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytoskeletal protein binding • structural constituent of cytoskeleton • GO:0001948, GO:0016582 protein binding • actin binding • structural constituent of muscle • identical protein binding • protein homodimerization activity • protein heterodimerization activity • actin filament binding Cydrannau o'r gell • cytoplasm • muscle thin filament tropomyosin • sarcomere • stress fiber • ruffle membrane • bleb • Cytosgerbwd • cytosol • Microffilament • actin cytoskeleton • Myoffibril • filamentous actin Prosesau biolegol • regulation of muscle contraction • muscle contraction • regulation of heart contraction • positive regulation of ATP-dependent activity • negative regulation of vascular associated smooth muscle cell migration • negative regulation of vascular associated smooth muscle cell proliferation • ruffle organization • wound healing • GO:0072353 cellular response to reactive oxygen species • negative regulation of cell migration • cytoskeleton organization • regulation of cell shape • muscle filament sliding • sarcomere organization • positive regulation of stress fiber assembly • positive regulation of cell adhesion • actin filament organization • in utero embryonic development • positive regulation of heart rate by epinephrine • ventricular cardiac muscle tissue morphogenesis • cardiac muscle contraction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7168	n/a
Ensembl	ENSG00000140416	n/a
UniProt	P09493	n/a
RefSeq (mRNA)	NM_000366 NM_001018004 NM_001018005 NM_001018006 NM_001018007 NM_001018008 NM_001018020 NM_001301244 NM_001301289 NM_001330344 NM_001330346 NM_001330351 NM_001365776 NM_001365777 NM_001365778 NM_001365779 NM_001365780 NM_001365781 NM_001365782	n/a
RefSeq (protein)	NP_000357 NP_001018004 NP_001018005 NP_001018006 NP_001018007 NP_001018008 NP_001018020 NP_001288173 NP_001288218 NP_001317273 NP_001317275 NP_001317280 NP_001352705 NP_001352706 NP_001352707 NP_001352708 NP_001352709 NP_001352710 NP_001352711 NP_001018006.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TPM1.

• CMH3
• TMSA
• CMD1Y
• LVNC9
• C15orf13
• HEL-S-265
• HTM-alpha

Llyfryddiaeth

• "Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle. ". Bull Exp Biol Med. 2016. PMID 27878731.
• "The impact of tropomyosins on actin filament assembly is isoform specific. ". Bioarchitecture. 2016. PMID 27420374.
• "The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics. ". Arch Biochem Biophys. 2017. PMID 28732641.
• "Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma. ". PLoS One. 2017. PMID 28182650.
• "Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin.". Biochemistry. 2017. PMID 27983818.