UMPS

Protein sy'n cael ei godio yn y corff dynol gan y genyn UMPS yw UMPS a elwir hefyd yn Uridine monophosphate synthetase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q21.2.

UMPS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4HKP, 2EAW, 2JGY, 2P1F, 2QCC, 2QCD, 2QCE, 2QCF, 2QCG, 2QCH, 2QCL, 2QCM, 2QCN, 2V30, 2WNS, 3BGG, 3BGJ, 3BK0, 3BVJ, 3DBP, 3EWU, 3EWW, 3EWX, 3EWY, 3EWZ, 3EX1, 3EX2, 3EX3, 3EX4, 3EX6, 3G3D, 3G3M, 3L0K, 3L0N, 3MI2, 3MO7, 3MW7, 4HIB
Dynodwyr
Cyfenwau	UMPS, OPRT, uridine monophosphate synthetase
Dynodwyr allanol	OMIM: 613891 HomoloGene: 319 GeneCards: UMPS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lyase activity • carboxy-lyase activity • transferase activity • catalytic activity • glycosyltransferase activity • orotidine-5'-phosphate decarboxylase activity • orotate phosphoribosyltransferase activity • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell Prosesau biolegol • female pregnancy • pyrimidine nucleotide biosynthetic process • UMP biosynthetic process • metabolaeth • nucleoside metabolic process • pyrimidine nucleoside biosynthetic process • 'de novo' UMP biosynthetic process • 'de novo' pyrimidine nucleobase biosynthetic process • lactation • pyrimidine nucleobase biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7372	n/a
Ensembl	ENSG00000114491	n/a
UniProt	P11172	n/a
RefSeq (mRNA)	NM_000373	n/a
RefSeq (protein)	NP_000364	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UMPS.

• OPRT

Llyfryddiaeth

• "A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis. ". Radiat Oncol. 2017. PMID 28347333.
• "Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences. ". J Inherit Metab Dis. 2017. PMID 28205048.
• "[Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy]. ". Nan Fang Yi Ke Da Xue Xue Bao. 2012. PMID 22931617.
• "Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. ". Pharmacogenomics J. 2013. PMID 22249354.
• "Frequency of uridine monophosphate synthase Gly(213)Ala polymorphism in Caucasian gastrointestinal cancer patients and healthy subjects, investigated by means of new, rapid genotyping assays.". Genet Test Mol Biomarkers. 2011. PMID 21631301.