USP14

Protein sy'n cael ei godio yn y corff dynol gan y genyn USP14 yw USP14 a elwir hefyd yn Ubiquitin specific peptidase 14 ac Ubiquitin carboxyl-terminal hydrolase 14 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18p11.32.

USP14
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AYN, 2AYO
Dynodwyr
Cyfenwau	USP14, TGT, ubiquitin specific peptidase 14, Ubp6
Dynodwyr allanol	OMIM: 607274 HomoloGene: 3780 GeneCards: USP14
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • proteasome binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • thiol-dependent deubiquitinase • cysteine-type endopeptidase activity • endopeptidase inhibitor activity • hydrolase activity • tRNA guanylyltransferase activity Cydrannau o'r gell • bilen • Cellbilen • synapse • cell surface • proteasome complex • extracellular exosome • cytoplasm • cytosol • GO:0016023 cytoplasmic vesicle • cnewyllyn cell Prosesau biolegol • regulation of proteasomal protein catabolic process • regulation of chemotaxis • ubiquitin-dependent protein catabolic process • proteolysis • negative regulation of ER-associated ubiquitin-dependent protein catabolic process • chemical synaptic transmission • negative regulation of endopeptidase activity • protein deubiquitination • immune system process • innate immune response • tRNA 5'-end processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9097	n/a
Ensembl	ENSG00000101557	n/a
UniProt	P54578	n/a
RefSeq (mRNA)	NM_005151 NM_001037334	n/a
RefSeq (protein)	NP_001032411 NP_005142	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn USP14.

• TGT

Llyfryddiaeth

• "Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer. ". Cell Physiol Biochem. 2016. PMID 26938858.
• "Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis. ". J Mol Histol. 2016. PMID 26712154.
• "Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells. ". Oncol Res. 2017. PMID 27629392.
• "Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma. ". Int J Biochem Cell Biol. 2016. PMID 27592452.
• "USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1.". Genes Dev. 2016. PMID 27542828.