WAS

Protein sy'n cael ei godio yn y corff dynol gan y genyn WAS yw WAS a elwir hefyd yn Wiskott-Aldrich syndrome (Eczema-thrombocytopenia), isoform CRA_a ac Wiskott-Aldrich syndrome (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.23.

WAS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CEE, 1EJ5, 1T84, 2A3Z, 2K42, 2OT0
Dynodwyr
Cyfenwau	WAS, SCNX, THC, THC1, WASPA, WASp, IMD2, Wiskott-Aldrich syndrome, WASP actin nucleation promoting factor
Dynodwyr allanol	OMIM: 300392 HomoloGene: 30970 GeneCards: WAS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phospholipase binding • GO:0005083 GTPase regulator activity • SH3 domain binding • GO:0001948, GO:0016582 protein binding • identical protein binding • actin binding • protein kinase binding • small GTPase binding • actin filament binding Cydrannau o'r gell • cytoplasm • cell-cell junction • vesicle membrane • actin cytoskeleton • extracellular exosome • Cytosgerbwd • cytosol • Microffilament • cnewyllyn cell • actin cortical patch • site of double-strand break • phagocytic vesicle Prosesau biolegol • defense response • Fc-gamma receptor signaling pathway involved in phagocytosis • actin filament organization • negative regulation of cell motility • blood coagulation • positive regulation of Arp2/3 complex-mediated actin nucleation • actin filament-based movement • endosomal transport • actin filament polymerization • regulation of T cell antigen processing and presentation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • epidermis development • actin polymerization or depolymerization • T cell receptor signaling pathway • T cell activation • GO:0048552 regulation of catalytic activity • Rho protein signal transduction • regulation of actin polymerization or depolymerization • regulation of lamellipodium assembly • Cdc42 protein signal transduction • regulation of stress fiber assembly • negative regulation of stress fiber assembly • actin cortical patch assembly • endocytosis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of actin nucleation • actin cortical patch localization • GO:0034622 protein-containing complex assembly • cellular response to interferon-gamma • positive regulation of double-strand break repair via homologous recombination • regulation of double-strand break repair via nonhomologous end joining Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7454	n/a
Ensembl	ENSG00000015285	n/a
UniProt	P42768	n/a
RefSeq (mRNA)	NM_000377	n/a
RefSeq (protein)	NP_000368 NP_000368.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WAS.

• THC
• IMD2
• SCNX
• THC1
• WASP
• WASPA

Llyfryddiaeth

• "Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion. ". BMC Cancer. 2017. PMID 28351346.
• "NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma. ". Oncogene. 2017. PMID 27694894.
• "Novel WASP mutation in a patient with Wiskott-Aldrich syndrome: Case report and review of the literature. ". Allergol Immunopathol (Madr). 2016. PMID 26993433.
• "Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. ". J Clin Invest. 2015. PMID 26368308.
• "Molecular characterization of two Malaysian patients with Wiskott-Aldrich syndrome.". Malays J Pathol. 2015. PMID 26277674.