YWHAE

Protein sy'n cael ei godio yn y corff dynol gan y genyn YWHAE yw YWHAE a elwir hefyd yn 14-3-3 protein epsilon a Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.3.

YWHAE
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BR9, 3UAL, 3UBW
Dynodwyr
Cyfenwau	YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Dynodwyr allanol	OMIM: 605066 HomoloGene: 100743 GeneCards: YWHAE
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transmembrane transporter binding • protein domain specific binding • GO:0032403 protein-containing complex binding • histone deacetylase binding • potassium channel regulator activity • phosphoprotein binding • GO:0001948, GO:0016582 protein binding • MHC class II protein complex binding • protein heterodimerization activity • enzyme binding • phosphoserine residue binding • ubiquitin protein ligase binding • cadherin binding involved in cell-cell adhesion • RNA binding • calcium channel regulator activity • identical protein binding • cadherin binding • scaffold protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • kinesin complex • focal adhesion • melanosome • axon • mitocondria • extracellular exosome • cytoplasmic vesicle membrane • cnewyllyn cell • Cellbilen • synapse • central region of growth cone • glutamatergic synapse Prosesau biolegol • protein targeting • negative regulation of protein dephosphorylation • GO:0007243 intracellular signal transduction • substantia nigra development • neuron migration • negative regulation of peptidyl-serine dephosphorylation • hippo signaling • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • G2/M transition of mitotic cell cycle • regulation of heart rate by hormone • regulation of potassium ion transmembrane transporter activity • cerebral cortex development • regulation of cellular response to heat • regulation of membrane repolarization • membrane organization • GO:0022415 viral process • regulation of heart rate by cardiac conduction • membrane repolarization during cardiac muscle cell action potential • hippocampus development • cell-cell adhesion • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • MAPK cascade • regulation of G2/M transition of mitotic cell cycle • protein localization to nucleus • cellular response to heat • positive regulation of protein export from nucleus • regulation of cytosolic calcium ion concentration • ciliary basal body-plasma membrane docking • regulation of postsynaptic membrane neurotransmitter receptor levels • negative regulation of calcium ion transmembrane transporter activity • negative regulation of calcium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7531	n/a
Ensembl	ENSG00000274474 ENSG00000108953	n/a
UniProt	P62258	n/a
RefSeq (mRNA)	NM_006761	n/a
RefSeq (protein)	NP_006752	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YWHAE.

• MDS
• HEL2
• MDCR
• KCIP-1
• 14-3-3E

Llyfryddiaeth

• "The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. ". Prog Neuropsychopharmacol Biol Psychiatry. 2014. PMID 24561237.
• "[Association of YWHAE gene polymorphism with suicidal behavior]. ". Genetika. 2013. PMID 24450199.
• "YWHAE-rearranged high-grade endometrial stromal sarcoma: Two-center case series and response to chemotherapy. ". Gynecol Oncol. 2017. PMID 28390819.
• "Aggressive behavior and poor prognosis of endometrial stromal sarcomas with YWHAE-FAM22 rearrangement indicate the clinical importance to recognize this subset. ". Int J Gynecol Cancer. 2014. PMID 25244606.
• "The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study.". PLoS One. 2014. PMID 25105667.